Depression caused by substances or medicines

What it is

Some substances and medicines can directly cause depressive symptoms. When a persistent low mood or loss of interest begins during or shortly after heavy use of a substance, during withdrawal from it, or after starting a new medication, and the substance is genuinely capable of producing those symptoms, clinicians call it a substance/medication-induced depressive disorder.

Alcohol is the most common example in our region: it is itself a depressant, and heavy regular drinking can create and sustain the very low mood people drink to escape. Withdrawal from stimulants (including khat) can produce a marked crash in mood. Among prescribed medicines, corticosteroids, some hormonal treatments and certain other drugs can affect mood in some people.

Why the distinction matters

Treatment changes. If alcohol is driving the depression, antidepressants alone will not fix it; the drinking has to be addressed, and mood often lifts considerably within weeks of stopping. If a prescribed medicine is responsible, the prescriber may adjust the dose or switch drugs. Never stop a prescribed medicine on your own; raise it with the prescriber.

This is also why honesty about alcohol, khat, cannabis and other substances during an assessment is so important, and why a good clinician asks without judgement. The information changes the diagnosis, and the diagnosis changes the help you get.

Substance-induced depression in the African context

In our region, alcohol is the most common driver, and because heavy drinking is widespread and often hidden, low mood caused or sustained by alcohol is frequently treated as depression alone while the drinking goes unaddressed. Khat withdrawal can produce a marked drop in mood, and medicines bought over the counter or prescribed long-term can affect mood too. Stigma keeps people from disclosing substance use, yet honest, non-judgemental conversation is exactly what lets a clinician find the real cause and treat it. See also our alcohol and depression guides.

What helps

The central step is addressing the cause.

• If alcohol or another substance is driving the low mood, reducing or stopping it, with support, often lifts mood within weeks, while medication aimed only at depression will underperform.
• If a prescribed medicine is responsible, raise it with the prescriber, who can adjust or switch it. Never stop a prescribed medicine on your own.
• Where withdrawal is involved, especially from alcohol, seek medical guidance, since some withdrawals are dangerous.
• If low mood persists well after the substance has cleared, it is then treated as depression in its own right.
• Be honest with your clinician about substances, since it directly changes the help you receive.